Concentrations of five microRNAs in saliva yielded 85% accuracy in identifying youths whose concussion symptoms persisted one month after injury, compared with about 65% accuracy using the Standardized Concussion Assessment Tool 3, researchers reported in the journal JAMA Pediatrics. The findings were based on data involving 52 children with concussions ages 7 to 21.
In a study in the journal Hepatology, researchers from University of Texas Health found that treatment with the drugs glecaprevir and pibrentasvir resulted in high rates of sustained virologic response in hepatitis C patients with genotypes 1 and 4 who did not respond to other direct-acting antivirals.
A joint team of investigators is studying how and where a malaria vaccine can be stabilized to create a stronger vaccine. The research seeks to gain an improved understanding of how the human immune system identifies malaria parasites using the RTS,S vaccine.
Days after the FDA granted approval for Genentech's hemophilia A candidate emicizumab, or Hemlibra, the company announced results from the HAVEN 3 study that showed the drug was linked with a significant decline in the rate of treated bleeds for patients treated weekly.
Although serum endomysial antibodies and antibodies to tissue transglutaminase tests are useful in screening for celiac disease in patients still eating gluten, the tests have low sensitivity for those with biopsy-confirmed celiac disease who are on gluten-free diets, a meta-analysis shows. "In the absence of a non-invasive biomarker, follow-up duodenal biopsy remains the only appropriate test to assess mucosal recovery in children and adults with celiac disease," researchers said.
Australian researchers have identified exosomal microRNA molecules that appear to be biomarkers for multiple sclerosis and could help in developing new diagnostic assays. The findings were reported in the journal Scientific Reports.
The FDA granted Grifols approval for its blood-based alpha-1 antitrypsin deficiency test for use with DNA extracted from a dry blood spot or a blood sample. The test is intended for the detection of 14 SERPINA1 mutations, which cause AAT deficiency, and enables simultaneous analysis of 192 samples per kit.
A study in the journal Supportive Care in Cancer found that supportive therapies for anemia resulted in better patient-reported outcomes for patients with lymphoma than those with multiple myeloma. The 250-person study also found that increases in hemoglobin levels were tied to improvements in fatigue and health-related quality of life. Supportive care consisted primarily of erythropoiesis-stimulating agents.
A new report in the journal The Lancet Infectious Diseases offers guidance on post-exposure prophylaxis of Ebola virus infection. The review describes six Ebola countermeasures as well as scenarios that warrant prophylaxis.
The European Centre for Disease Prevention and Control reports that antimicrobial resistance is increasing in 30 countries in the European Union and European Economic Area, particularly for Escherichia coli and the Acinetobacter species. A significant decrease, however, was seen in rates of methicillin resistance among Staphylococcus aureus from 2013 to 2016.
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