A study of pregnant monkeys suggests that Zika virus may be more dangerous to human pregnancies than previously thought. Among four pregnant macaque monkeys infected with the amount of virus equivalent to that from a mosquito bite, the virus was later found in all four fetuses. Atypical inflammation of the eyes, optic nerves and retinas were detected in fetuses infected in the first trimester. The study was funded by NIH and published in the journal PLOS Pathogens.
Emmaus Life Sciences' oral L-glutamine, or Endari, has received positive feedback from the FDA's Oncologic Drugs Advisory Committee. The drug is being reviewed as a treatment for sickle cell disease in adults and children.
A study in the journal Nature found that the mosquitoes that spread the Zika virus in Florida last year had been circulating in the area about three months prior to infections being reported. Genetic information studies indicated that the Zika virus that spread in Florida mosquitoes mainly came from the Caribbean, researchers said.
Blood banks in Manchester, UK, were overwhelmed by the large number of people wanting to donate blood after a bombing at an Ariana Grande concert. "We plan ahead to build in reserves to deal with major incidents. We hope that people who want to help will now become regular donors, because that is how they can best help us save lives when there is a tragedy," writes Jane Green, chief nurse and assistant director of blood donation operations at the UK's NHS Blood and Transplant. Green describes the process of how blood is collected and takes weeks to prepare for use.
A formal vaccine trial protocol has been submitted by the government of the Democratic Republic of the Congo to test an unapproved Ebola vaccine. The World Health Organization is seeking $10.5 million in donations to support the trial.
An investigative malaria vaccine has been modified by scientists with the National Institute of Allergy and Infectious Diseases, resulting in protection of half of monkeys in a Plasmodium falciparum challenge. The AMA1-RON2L vaccine generated antibodies for parasite strains other than those used to develop the vaccine, according to the study in the journal Nature.
Progenza stem cell technology developed by Regeneus has been granted a patent in Japan.
Sandra Jean Ingleton, a former mayor of Louth, England, who died at 77 and who had long lived with multiple sclerosis, donated her body to the Multiple Sclerosis Society Tissue Bank to support research. "She decided about 10 years ago that she would donate her body to science, as her father also had MS and he did the same," said Phillip Ingleton, her husband.
The eye banking world refers to the journey that tissue makes from donor to recipient as the "cycle of giving," writes Diane Hollingsworth, executive director of Illinois Operations of Eversight. Advances in state policies and in the field of eye banking have made corneal transplants the most common form of transplant, Hollingsworth writes.
Xenetic Biosciences reported that a Phase I/II study of Shire's SHP656 hemophilia A treatment candidate missed the study's goal of establishing weekly dosing.
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