Lab Sciences
Top stories summarized by our editors
2/15/2019

Preliminary data from a late-stage clinical trial showed that patients with hematologic malignancies who received umbilical cord blood grafts expanded ex vivo with nicotinamide, or NiCord, had median post-transplant neutrophil recovery time decreased by almost 50% compared with patients who received standard UCB transplantation, and incidence of graft-versus-host disease was also lower in patients receiving NiCord cells. "This study suggests that NiCord obviates the need for a second UCB graft. NiCord paves the way for use of smaller, better-matched units for adult patients that otherwise could not be used because of excessive risk of graft failure," the study team wrote in the Journal of Clinical Oncology.

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UCB, nicotinamide
2/15/2019

Medicare would cover chimeric antigen receptor T-cell therapies approved by the FDA under a proposal from the CMS, which would include Kymriah, or tisagenlecleucel, and Yescarta, or axicabtagene ciloleucel. The proposed National Coverage Determination would cover CAR T-cell therapies offered through clinical trials or CMS-approved registries, according to the CMS.

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MarketWatch
2/15/2019

A study in the journal Blood found that absence of the protein CDK6 in mouse models of JAK2V617F-initiated myeloproliferative neoplasms was associated with reduced stem cell proliferation and increased cell death. The study team said CDK6 plays a role in inhibiting apoptosis and activating the inflammation-regulating protein NFkB, as well as being involved in malignant stem cell function.

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Rare Disease Report
2/14/2019

A prospective study found that survival was longer with consolidative autologous stem cell transplants during the first complete remission for patients with nodal peripheral T-cell lymphoma who had intermediate to high scores on the International Prognostic Index or who had advanced-stage disease. Median overall survival was 57.6 months for patients who did not get ASCT, and the median had not yet been reached at 2.8 years for the ASCT group.

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Medical Xpress
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peripheral T-cell lymphoma, HSCT
2/14/2019

A trial in the Democratic Republic of Congo of four Ebola treatment candidates is expanding to the current hot spots of Katwa and Butembo. The total number of cases in the current Ebola outbreak has reached 823.

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Ebola
2/13/2019

A new nanotech-based microchip was able to identify antibodies that indicate the early stages of type 1 diabetes one year earlier in two of six patients who developed diabetes during the study, and four years earlier in one individual, compared with traditional methods that could detect antibodies in the latter stages of diabetes development, according to a study in the journal PLOS ONE. Findings were based on 14 individuals with and without diabetes from the TrialNet study.

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Diabetes (UK)
2/13/2019

Innovate UK awarded SAW Diagnostics a grant worth approximately $1.9 million to support development of its integrated sample processing technology platform for detecting infectious diseases and other applications. The low-cost, point-of-care system is designed to allow molecular detection from complex clinical sample types.

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Innovate UK
2/13/2019

Quest Diagnostics has finalized its previously announced acquisition of Boyce & Bynum Pathology Laboratories' clinical laboratory services business in the Midwest. BBPL, a provider of clinical laboratory and diagnostic services, was also tapped to be Quest's exclusive pathology provider in Missouri.

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ROI-NJ (New Jersey)
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Quest Diagnostics, Boyce
2/13/2019

An underwritten public offering of 6.25 million shares of common stock and warrants has been priced by liquid biopsy solution company Biocept in hopes of raising about $7.5 million.

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Biocept
2/13/2019

Scientists from Harvard University's Wyss Institute are developing vascularized kidney organoids to allow for more accurate modeling of mature kidney functions, according to a study in the journal Nature Methods. The study team said that culturing the organoids in an environment of fluid flow promoted the development of vasculature.